After the recent soup attack on Leonardo da Vinci’s masterpiece, the Mona Lisa, fortunately protected by bulletproof glass, we reached out to the renowned Senior Expert Artworks Conservator & Restorer, Venizelos G. Gavrilakis, also known as ‘The Art Doctor’, to understand the potential ramifications if the most famous painting in the world were exposed not only to soup but also to some of the most detrimental substances readily available to the public. In our theoretical scenarios, the beloved Mona Lisa faces attacks by various substances, ranging from mundane to malicious, including soup, oil paint, ink, bleach, acid, and worst of all, paint remover. Mr. Gavrilakis outlines the potential damage for each scenario and discusses the necessary conservation and restoration efforts needed to save the masterpiece. As the fate of this iconic artwork hangs in the balance, we explore each horrific scenario, delving into the potential extent of damage and, above all, the restoration efforts required.