The International Conference, Leonardo The Immortal Light, held at Palazzo Li Madou in Ancona, unveiled a groundbreaking study on Leonardo da Vinci’s red chalk drawing, revealing that it depicted the features of Federico da Montefeltro, the Duke of Urbino. The event, now in its 30th edition, explored Leonardo’s genius through scientific research, philosophy, and art, with renowned experts presenting their findings. The conference also highlighted the role of Neoplatonism during the Renaissance, the symbolism employed by Federico at his court, and the anatomical details of the drawing. The event culminated in the awarding of the prestigious Leonardo International Award to the Marche Region for its commitment to culture, tourism, and sustainability. The discoveries made during the conference underscored the profound connection between the Marches and Leonardo’s works, emphasizing the need for a new humanism that unites spirituality and intellectual achievements. The event serves as a catalyst for cultural rebirth, inspiring further research and appreciation of Leonardo’s legacy, while envisioning a future where art, science, and philosophy intertwine to shape a harmonious society.